Hematopoietic cancer cells apoptosis

Concerning NO implication in hematopoietic cancer cells apoptosis, the situation is less clear. In U937 and HL60 cells, NO effects are very different although both cell lines have been established in culture from promyelocytic leukemia. NO-induced apoptosis in U937 cells (p53 negative cells) is a p53 and caspase independent pathway but is controlled by Bcl-2 [124]. In these cells NO inhibits caspase 3 by S-nitrosation... 

The CaR regulates numerous biological processes, including the expression of various genes (e.g., PTH) the secretion of hormones (PTH and calcitonin), cytokines (MCP-1), and calcium (e.g., into breast milk) the activities of channels (potassium channels) and transporters (aquaporin-2) cellular shape, motility (of macrophages), and migration cellular adhesion (of hematopoietic stem cells) and cellular proliferation (of colonocytes), differentiation (of keratinocytes), and apoptosis (of H-500 ley dig cancer cells) [3]. 

OH)2D3 inhibited proliferation and induced differentiation and apoptosis in human colon, breast, prostate and gynecological cancers as well as several forms of hematopoietic cancer (Studzinski and Moore, 1995 van Leeuwen and Pols, 1997). Experimental animal studies show that 1, 25(OH)2D3 inhibited chemically-induced breast, colon, and skin tumors. The growth of colon, breast and prostate cancer cells, as well as melanoma and retinoblastoma cells implanted into rodents was retarded by treatment with 1, 25(OH)2D3 (Studzinski and Moore, 1995 van den Bemd et al, 2000). 

The oil has antimutagenic and antihepato-carcinogenic effects both in vivo and in vitro Citral is also an inducer of cas-pase-3 and apoptosis in hematopoietic and cancer cell lines at 44.5... 

---