Heliobacter

Winkler, M. A. Uher, I Cepa, S. Direct analysis and identification of Heliobacter and Camphlobacter species by MALDI-TOF mass spectrometry. Anal. Chem. 1999, 71, 3416-3419. 

Other therapies that potentially could benefit from controlled delivery of drug directly to the stomach are treatments for local disorders of the stomach such as Heliobacter pylori infections.8,9... 

Baumgartner, S., Tivadar, A., Vrecer, V., and Kristi, J. Development of floating tablets as a new approach to the treatment of Heliobacter pylori infections. Acta Pharm. 51 21-33, 2001. 

Microbiol. 13, 308-313, 2005 Lu, H., Yamaoka, Y, and Graham, D.Y, Heliobacter pylori virulence factors fact and fantasies, Curr. Opin. Gastroenterol. 21, 653-659, 2005 Zaas, D.W., Duncan, M Rae Wright, J., and Abraham, S.N., The role of lipid rafts in the pathogenesis of bacterial infections, Biochim. Biophys. Acta 1746, 305-313, 2005 Kazmierczak, M.J., Wiedmann, M., and Boor, K.J., Alternative sigma factors and their roles in bacterial virulence, Microbiol. Mol. Biol. Rev. 69, 527-543, 2005 Yates, S.R, Jprgensen, R., Andersen, G.R. et al.. Stealth and mimicry by deadly bacterial toxins. Trends Biochem. Sci. 31,123-133,2006. 

Detection of Heliobacter pylorii The Heliobacter pylorii bacterium is found in the mucous membrane of the stomach and is the major cause of gastritis, gastric ulcers and cancer of the stomach and duodenum. It produces urease by cleaving urea to form ammonia and CO2. The detection of this dangerous bacterium is possible by administering a small amount (100 mg) of C-labelled urea to the patient and measuring the value of breath CO2. If after 30 min an increase in the of the breath-C02 is detected, the bacterium is present and actively forming C-enriched CO2 from the labelled urea. This noninvasive procedure is simple to administer and is widely applied as a urea breath test by a number of medical laboratories. 

---