Heck reaction industrial fine chemicals synthesis

Finally there are a number of very practical reasons which make supported palladium metal systems an attractive catalyst for organic synthesis in the laboratory and industrial fine chemical synthesis The most interesting catalysts do not need additional ligands like phosphines. It is not necessary to work under an inert atmosphere. The high thermal stability of supported palladium metal catalysts allows the use of higher temperatures for Heck reactions. The resulting higher reaction rate makes it possible to achvate less reachve aryl bromides and aryl chlorides in some cases. 

Another catalytic methodology that is widely used for C-C bond formation is the Heck and related coupling reactions [86, 87]. The Heck reaction [88] involves the palladium-catalysed arylation of olefinic double bonds (Fig. 1.31) and provides an alternative to Friedel-Crafts alkylations or acylations for attaching carbon fragments to aromatic rings. The reaction has broad scope and is currently being widely applied in the pharmaceutical and fine chemical industries. For example, Albemarle has developed a new process for the synthesis of the anti-in-... 

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