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Heart failure pharmacokinetic changes

Edema and cardiac output changes with severity of heart failure may alter pharmacokinetic parameters... [Pg.159]

The use of beta blockers with felodipine, isradipine, lacidipine, nicardipine, nimodipine and nisoldipine normally appears to be useful and safe. However, severe hypotension and heart failure have occurred rarely when a beta blocker was given with nifedipine or nisoldipine. Changes in the pharmacokinetics of the beta blockers and calcium-channel blockers may also occur on concurrent use, but they do not appear to be clinically important. [Pg.838]

In 10 patients with heart failure nisoldipine 20 mg daily increased the plasma trough digoxin levels by about 15%.Nisoldipine 10 mg twice daily caused no changes in the pharmacokinetics or haemodynamic effects of digoxin in 8 healthy subjects. ... [Pg.914]

Nimesulide 100 mg twice daily for 7 days had little effect on the pharmacokinetics of digoxin 250 micrograms daily in 9 patients with mild heart failure. No major change in their clinical condition occurred. ... [Pg.933]

See other pages where Heart failure pharmacokinetic changes is mentioned: [Pg.611]    [Pg.343]    [Pg.1432]    [Pg.389]    [Pg.586]    [Pg.662]    [Pg.93]    [Pg.62]    [Pg.185]    [Pg.151]    [Pg.839]    [Pg.855]    [Pg.856]    [Pg.912]    [Pg.925]    [Pg.239]   
See also in sourсe #XX -- [ Pg.128 ]



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Heart failure pharmacokinetics

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