Headache telithromycin

MODAFINIL 1. ANTIBIOTICS-clarithromycin, telithromycin 2. ANTIFUNGALS-itraconazole, ketoconazole 3. ANTIVIRALS-indinavir, nelfinavir, ritonavir, saquinavir t plasma concentrations of modafinil, with risk of adverse effects Due to inhibition of CYP3A4, which has a partial role in the metabolism of modafinil Be aware. Warn patients to report dose-related adverse effects, e.g. headache, anxiety... 

A meta-analysis comparing telithromycin with clarithromycin reviewed data from five randomised controlled trials. Adverse events were similar in both groups. Common adverse events included diarrhoea, nausea, vomiting, flatulence, dyspepsia and abdominal pain. Other events included headache, oral candidiasis, dizziness, dysgeusia, abnormal liver function tests and fatigue. Serious adverse events included allergic reactions, abnormal liver function tests as well as death (in three cases) [86 ]. 

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See also in sourсe #XX -- [ ]

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