Harmine Heart

Cardiovascular effects Harmala alkaloids have cardiovascular effects (Aarons et al. 1977). Harmine, harmaline, and harmalol decrease heart rate, but increase pulse pressure, peak aortic flow, and myocardial contractile force in dogs. Harmine reduces systemic arterial blood pressure and peripheral vascular resistance. Vascular resistance effects are not mediated by jS-adrenergic or histamine HI receptors. 

DMT elevates pulse rate and blood pressure. In one study, heart rate elevated from around 70 beats per minute at baseline to 100 beats per minute at the highest dose (0.4 mg/kg, IV). Neurophysiological effects Harmane produces excitation in the nucleus accumbens in nanomolar concentrations, but depression in micromolar concentrations (Ergene and Schoener 1993). Harmine and B. caapi extract decrease the acoustic startle, which is reversed to some degree by DMT (Freedland and Mansbach 1999). j3-carbolines may have antioxidant effects through inhibiting oxidative enzymes in the microsomal system (Tse et al. 1991). 

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