Halothane reductive dehalogenation

Ahr HJ, King LJ, Nastainczyk W, et al. The mechanism of reductive dehalogenation of halothane by liver cytochrome P450. Biochem Pharmacol 1982 31 (3) 383—390. 

Reductive dehalogenation reactions catalyzed by P-450 have been studied extensively, primarily because of the interest in compounds such as anesthetics, pesticides, and potentially toxic industrial solvents. An anesthetic named halothane gives anion-radical that undergoes dehalogenation according to the following equation ... 

Halothane (2) offers a telling example of the metabolic fate of halogenated compounds of medicinal interest. Indeed, this agent undergoes two major pathways, oxidative dehalogenation leading to trifluoroaceticacid (3)and reduction producing a reactive radical (4) (Fig. 13.4). 

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