Haloperidol smoking

CHLORPROMAZINE, CLOZAPINE, HALOPERIDOL, OLANZAPINE BUPROPION T plasma concentrations of these drugs with risk of toxic/adverse effects Smoking induces mainly CYP1A2 and CYP2E1. Thus de-induction takes place following cessation of smoking Be aware and watch for early features of toxicity. Consider reducing the dose... 

CANNABIS ANTIPSYCHOTICS -CLOZAPINE, OLANZAPINE, HALOPERIDOL i plasma levels of these antipsy-chotics (plasma concentrations of clozapine may be halved), with the risk of therapeutic failure Induction of CYP1 A2-mediated metabolism by any form of smoking. Foods (e.g. broccoli, cabbage, Brussels sprouts, chargrilled meat) also induce this isoenzyme Watch for poor response to these antipsychotics conversely, watch for toxic effects of these antipsychotics if a previously heavy cannabis user stops smoking... 

McEvoy, J.P., Freudenreich, O., Levin, E.D., Rose, J.E., 1995a. Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology 119, 124-126. 

Barbiturates and heavy smoking induce nortriptyline metabolism and decrease therapeutic efficacy phenothiazines and haloperidol decrease its metabolism, decreasing therapeutic efficacy methylphenidate, cimetidine, oral contraceptives, propoxyphene, and beta-blockers may inhibit nortriptyline metabolism, increasing plasma levels and toxicity (see Tables 5 through 7). 

Heavy smoking accelerates temazepam metabolism, thus lowering clinical effectiveness. Benzodiazepines block the therapeutic effects of levodopa. Temazepam may decrease plasma levels of haloperidol. 

A2 Benzo[a]pyrene (from tobacco smoke), carbamazepine, phenobarbital, rifampin, omeprazole Acetaminophen, clozapine, haloperidol, theophylline, tricyclic antidepressants. (R)-warfarin... 

Mnltiple linear regression analysis showed a significant interaction between the variables of smoking. The haloperidol plasma concentration-to-dose relationship was best described by Eqnation 9.1 for nonsmokers and Eqnation 9.2 for smokers. 

Jann MW, Saklad Ereshefdcy L, Richards AL, Hanii on CA, Davis CM Effects of smoking on halc Teridol and redu< haloperidol plaana concentrations and haloperidol clearance. P duqrharmacology (Berl) (198 90,468-70. 

Possibly. Sufferers from Tourette s syndrome are helped by using a nicotine patch to stimulate the haloperidol medicine they are taking. It is also believed that smokers are less likely to contract Parkinson s disease, but smoking is a rather drastic way to get those benefits. 

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