Halogen-resistant inhibitors

A new halogen-containing member of the penitrem family of indole-diterpe-noids, which have insecticidal activity (1397), is thomitrem A (1466) from Penicil-lium crustosum (1398). The novel dichlorinated calmodulin inhibitor, malbrancheamide (1467), was characterized from the fungus Malbranchea auran-tiaca (1399). The microbe Streptomyces rugosporus produces pyrroindomycin B (1468), which is active against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci (1400). The Chinese shrub Acacia confusa has yielded the unusual chlorotryptamine alkaloid 1469, which does not appear to be an artifactual dichloromethane adduct (1401). 

The resistance of aluminum alloys to halogenated hydrocarbons tends to decrease as the temperature is raised and the rate of corrosion in many liquid halogenated hydrocarbons remains low until the boiling point is reached in some, it is low or non-existent even at this temperature. Other factors that affect resistance include the presence of an inhibitor and the purity of a halogenated hydrocarbon amines or various heterocyclic compounds have been effectivebF used as inhibitors in certain cases. 

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