Streptomyces rugosporus

A new halogen-containing member of the penitrem family of indole-diterpe-noids, which have insecticidal activity (1397), is thomitrem A (1466) from Penicil-lium crustosum (1398). The novel dichlorinated calmodulin inhibitor, malbrancheamide (1467), was characterized from the fungus Malbranchea auran-tiaca (1399). The microbe Streptomyces rugosporus produces pyrroindomycin B (1468), which is active against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci (1400). The Chinese shrub Acacia confusa has yielded the unusual chlorotryptamine alkaloid 1469, which does not appear to be an artifactual dichloromethane adduct (1401). 

Ding W, Williams DR, Northcote P, Siegel MM, Tsao R, Ashcroft J, Morton GO, Alluri M, Abbanat D, Maiese WM, Ellestad GA (1994) Pyrroindomycins, Novel Antibiotics Produced by Streptomyces rugosporus sp. LL-42D005 I. Isolation and Structure Determination. J Antibiot 47 1250... 

Zehner S, Kotzsch A, Bister B, Siissmuth RD, Mendez C, Salas JA, van Pee K-H (2005) A Regioselective Tryptophan 5-Halogenase Is Involved in Pyrroindomycin Biosynthesis in Streptomyces rugosporus LL-42D005. Chem Biol 12 445... 

Prod, by a strain of Streptomyces rugosporus. Active against gram-positive bacteria. 

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