Halides, alkyl, base induced reagents

Rappoport has presented a detailed outline of the mechanisms of the reactions of vinyl halides with nucleophilic reagents. Modena et /. " have provided further evidence in support of a spectrum of transition states for elimination from activated vinyl halides induced by alkoxide bases. Cristol and Whittemore have shown that the stereoselectivity of elimination from vinyl halides is largely determined by the choice of basic reagent alkoxide bases encourage am/-elimination, whereas syn-elimination and alpha-elimination become dominant with lithium alkyls. 

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