Haliclona nigra from Papua New Guinea

The cyclic hexapeptide, waiakeamide (447) was isolated from an Indonesian collection of Ircinia dendroides [373]. Haliclona nigra from Papua New Guinea contained two cyclic hexapeptides, haligramides A (448) and B (449). They showed an unusual activity pattern in the National Cancer Institute (NCI) 60 cell-line panel [374],... 

Investigations of the sponge Haliclona nigra from Papua New Guinea led to the isolation of two new cyclic hexapeptides, haligramides A 364 and B 365, in addition to the known peptide, waiakeamide 366 <2000JNP956>. The structures of peptides 364 and 365 were elucidated by extensive NMR analyses and by comparison of their spectral data with those of 366. The identity of 365 was confirmed by its oxidative conversion into 366. 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

---