Halfordia scleroxyla

Natural product o-methylhalfordinol 117 is a basic principle of the oxa-zole alkaloids of Halfordia scleroxyla and Aegle marmelos. Annuloline 119, a blue fluorescent pigment, has been isolated from the roots of rye stalk Lolium multifiorum. The total synthesis of 2,5-disubstituted oxazole alkaloids o-methylhalfordinol and annuloline is based on the aza-Wittig reaction (Scheme 48). Thus 4-methoxyphenacylazide 115, triphenylphos-... 

Halfordia scleroxyla F. Muell. and H. kendack (Rutaceae) (ref. 33b, p. 565) Details concerning the structural elucidation of the pyridine-oxazole alkaloids (14) have been reported. Interestingly, furoquinolines are found in the same plant species. 

Halfordinine, C15H15N05, a minor component of the bark of Halfordia scleroxyla, was isolated by Crow and Hodgkin (22). There was insufficient material for a full structural investigation, but the alkaloid was shown to be a trimethoxydictamnine on the basis of the NMR spectrum. Halfordinine (mp 150-151°) clearly was not identical with 5,7,8-trimethoxydictamnine (acronycidine) (mp 136-137°). Halfordinine has been obtained recently from the leaves of Melicope perspicuinervia Mer. and Perry. Murphy, Ritchie, and Taylor (42) noted that the NMR signal at t2.69 indicated that... 

Halfordamine 4,6,8-triOMe Agathosma bisulca, A. capensis, A. sp. nov. [21], Halfordia scleroxyla [44]... 

Halfordinine I 4,6,7,8-tetraOMe Araliopsis tabouensis [44], Diphasia angolensis [44], Halfordia scleroxyla [44], Melicope leptococca [18], M. perspicuinervia [44], Nematolepis phebalioides [28], Oricia suaveolens [44], Sarcomelicope argyrophylla [21], Teclea verdoorniana [44]... 

Hegarty M P, Lahey F N 1956 The coumarins of Halfordia scleroxyla. Aust J Chem 9 120-131... 

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