Haemadsorption

Many viruses have antigens which adsorb to and cross-link red blood cells. When the antigens are expressed on the surface of infected cells, these cells will adsorb red blood cells (haemadsorption). 

A variety of structures based on the trans-decalin nucleus have recently been reported to have activity against influenza A (strain DSP) in tissue culture [89]. The cellular toxicity, based on the principle that healthy cells take up the dye neutral red, whereas unhealthy or dead cells take up less or none, was generally very low, whereas some activities determined by quantitative haemadsorption [90] were extremely high. Three types of active compound (XVII-XIX) were described. 

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