Guthrie screening test

Screening tests, including thin layer chromatography (TLC), urine color tests, and the Guthrie microbiological test. (Details of these tests are given in a previous edition of this textbook.) ... 

The screening test for phenylketonuria (PKU) is called the Guthrie test. Based on this screening method, which of the following is the most likely explanation of a false-negative screen in a newborn ... 

M53 Murphey, W. H., Patchen, L. and Guthrie, R. Screening tests for argininosuccinic aciduria, orotic aciduria and other inherited enzyme deficiencies using dried blood specimens. Biochem. Genet., 6, 51-59 (1972)... 

The simplicity and reliability of the Guthrie test made it the basis for newborn screening programs around the world. Today, the Guthrie screen-... 

Screening for a BH4 deficiency should be done in all newborns with plasma phenylalanine levels higher than 120 pmol/1, as well as in older children with neurologic signs and symptoms [10]. The following tests are recommended (1) analysis of pterins in urine, (2) measurement of DHPR activity in blood from a Guthrie card,... 

During the past 20 years, neonatal screening programs using the Guthrie test for inborn errors of metabolism such as phenylketonuria have become more widely used. The characteristics of diseases in which mass screening is... 

Two patients were missed in the newborn screening due to the negative Guthrie test. 

The phenylalanine concentration may be measured in blood either by chemical estimation or by microbiological assay (the Guthrie test, q.v.). The latter technique can be used as a screening procedure. 

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