Gustatory stimulant effect

As noted earlier, it is scienti cally valid to evaluate the safety of a natural mixture based on its chemical composition. Fundamentally, it is the interaction between one or more molecules in the natural product and macromolecules (proteins, enzymes, etc.) that yield the biological response, regardless of whether it is a desired functional effect such as a pleasing taste or a potential toxic effect such as liver necrosis. Many of the advertised bene cial properties of ephedra are based on the presence of the central nervous system stimulant ephedrine. So too, the gustatory and olfactory properties of coriander oil are, in part, based on the binding of linalool, benzyl benzoate, and other molecules to the appropriate receptors. It is these molecular interactions of chemical constituents that ultimately determine conditions of use. 

Summary of Behavioral Effects of Depleting 5-HT with PCPA in Animals - Although isolated animals treated with PCPA show few symptomatic effects, exposure of animals to novel exteroceptive stimulation evokes behavioral hyperresponsiveness. Animals overreact to painful, electrical, auditory, visual, gustatory, olfactory and especially social stimuli. The sustained wakefulness of animals treated with PCPA may feasibly be considered one manifestation of this generalized hyperresponsiveness. 

The physiological variables included (l) afferent stimulation from olfactory gustatory and somatosensory receptors in the head, (2) both immediate and long-term consequences of ingestion (i.e., sensory and/or metabolic effects), and (3) the interaction of afferent stimulation and postingestive consequences which modify preference and ingestive behavior. 

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