Guinea pigs cyanide exposure

When the skin of rabbits was exposed to 5,000 ppm cyanide as cyanogen for 8 hours, no dermal lesions were found (McNemey and Schrenk 1960). Vascular congestion was reported in the skin of guinea pigs after exposure to unknown doses of hydrogen cyanide for 65 minutes (Fairley et al. 1934). 

A skin redness reported in experimental animals (rats, rabbits, cats and monkeys) after inhalation exposure to acrylonitrile may be due to a vasodilatory effect, rather than a direct irritant action (Ahmed and Patel 1981). Guinea pigs, which do not exhibit the cyanide-type effects of acrylonitrile poisoning (see Section 2.2.1.4), were observed to have nose and eye irritation from the acrylonitrile vapors (Dudley and Neal 1942). 

Acute dermal exposure of guinea pigs to an unknown concentration of hydrogen cyanide resulted in submucous hemorrhages in the stomach as observed at necropsy (Fairley et al. 1934). 

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