Guanosine Self-Assembly in Water

The cyclic G-quartet structure was first identified in 1962 as the basic building block for formation of hydrogels by 5 -GMP I. Using fiber 

5] 16- 3K jCs 4Pic showing a G-quartet, without the sugars, with a cation bound above the plane of the G-quartet (Adapted from ref 3 with permission). 

G-quadruplexes formed from 5 -GMP in water underscores the highly cooperative participation of hydrogen bond, ion-dipole, and n-n stacking interactions inherent to these G-quartet based assemblies. 

As described in more detail later in this chapter, Lehn s study is a unique example of using dynamic covalent chemistry (DCC), with G-quartets as a scaffold, to control phase-organization. 

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