Guanosine palladium complexes

OjNjQHis, Cytidine palladium(II) complexes, 23 54 OSN4C10H12, Inosine palladium(II) complexes, 23 51-54 OsH CioHi3, Guanosine palladium(II) complexes, 23 51-54 OsUCioHij, Uranium(V), pentaethoxy-, 21 165... 

Coordination Compounds. Palladium forms numerous complexes with ammonia and with simple amines. Examples are [Pd(NH3)4]2+ [15974-14-8], [PdCl(dien)]+ [17549-31-4], cis-[PdCL (NH3)2] [15684-18-1], and trans-[PdC (NH3)2] [13782-33-7]. Monoammine complexes such as [PdCl3 (NH3)] [15691-32-4] are stable but less common. Examples of aromatic amine complexes include trans- [PdCf (pyr)2] [14052-12-1], [PdCl2(bipy)] [14871-92-2], and nucleosides such as [PdCl(dien)(guanosine)]+ [73601-42-0] (193). Complexes of Pd(IV) such as [PdCl2(NH3)4]2+ [70491-81-5] and [PdCl4(bipy)] [57209-01-5] may be prepared by chlorine oxidation of the corresponding Pd(2+). The aromatic amine Pd(IV) complexes are more stable than ammine and aliphatic amine species, which are reduced to Pd(II) in water or thermally (194). 

Group 10 Systems. Proton NMR spectra gave values for association constants for the formation of inclusion complexes of mononucleotides and the metallacalix[3]arene species, [(/ ,R-1,2-diaminocyclohexane)Pd(phen)]36+.1074 Similar experiments were used to probe the binding of palladium(II) complexes, e.g. [Pd(en)(H20)2](N03)2, to guanine, guanosine and guanosine-5 -monophos-phate in aqueous solution.1075... 

Two mmoles of the corresponding cis-[dichlorobis(nucleoside)palladium(II)] (1.4274 g for the inosine and 1.4882 g for the guanosine complex) are placed in a 100-mL beaker containing a magnetic stirring bar. Upon addition of about 50 mL of distilled water (with stirring) the initial complex dissolves, and, almost instantaneously (after 10-15 min for inosine), a new, yellow precipitate is formed. The pH of this water suspension becomes acidic, due to the liberation of HC1. The stirring is continued for about two hours to attain completion of the reaction, while the pH is kept between 6.0 and 6.5 by the dropwise addition of a solution of 0.1 N KOH. The final pH value of the suspension should be 6.0-6.5. 

SnMe2Cl2(adenine)2 and SnPhCl2(0H)(Adenine)2 thought to involve N-7 of the bases.Treatment of Inosine and guanosine with palladium chloride in acid gave a set of complexes... 

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