Guanine zinc complexes

The interaction of nine nucleobases (thymine, uracil, dihydrouracil, cytosine, adenine, guanine, diaminopurine, xanthine, hypoxanthine), in their deprotonated form, with zinc and with themselves in [Zn(nucleobase)(Tpph Me)] has been investigated. Selected compounds have been characterized by single-crystal X-ray study.158 Gelinski et al. reported the synthesis and characterization of two zinc complexes containing the ligand Tpph,Me and glutathione derivatives (Fig. 3.28).159... 

A number of zinc and cadmium complexes of adenine (82),554,555 adenine N-oxide,556 guanine,557 inosine,558 cytidine559 and other nucleosides560 have been studied. The structure of (9-methyladenine)ZnCl2 is polymeric each zinc ion is tetrahedrally coordinated to two chlorine atoms (Zn—Cl = 2.22 A), and to N-l and N-7 of neighbouring adenine moieties (Zn— N = 2.05A).561 A structural study of the related cadmium complex, CdCl2(DMSO)L (L = 9-methyladenine), has shown the complex to form a one-dimensional polymer. 2... 

Ruthenium(II) A range of complexes of the type [Ru(L)(NH3)j] + (e.g. L = pyridine, pyridazine, pyrazine, pyrimidine,triazine, 2-cyanopyridine, 3-cyanopyridine, 4-cyan-opyridine, 2-, 3- and 4-RC(0)-substituted pyridines (R = CHMe2, CH2Et, CHjPr, OMe, NH2, OH, H, Ph ), IV-methylpyrazine, 4,4 -bipyridine, l,2-bis(4 -pyridyl)ethylene," hyp-oxanthine, guanine, xanthine,4-dimethylaminopyridine" ) have been prepared by reaction of [RuCl(NH3)j]Cl2 with a Ag" salt (AgOjCCF3 is often used) followed by zinc amalgam reduction... 

In related work, Harriman et al. [77] reported the synthesis of a cytosine derivative possessing an appended benzo-l,4-quinone moiety (14). Mixing in chloroform solution with the zinc porphyrin bearing a guanine residue resulted in the formation of a 1 1 complex due to formation of a 3-point hydrogen bond between the nucleic acid bases. The association constant was found to be 1290 M and fluorescence from the porphyrin was found... 

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