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Guanine binding with metals

The PDB structure of DNA polymerase p with 7 base pairs of DNA and ATP bound (PDB SICE) contains just one binding site in which DNA is involved. The cadmium(II) has contacts to four different amino acids and two phosphate oxygens it is also in coordination distance to 05 of adenine and 03 of a guanine. Additionally, four oxygen atoms of pyrophosphate coordinate the Cd ". This is a good example of how DNA-Cd contacts can be facilitated by another main binding site. In this case, the pyrophosphate is required to bind a metal ion in this site as in its absence the site remains unoccupied [285]. [Pg.261]

See other pages where Guanine binding with metals is mentioned: [Pg.201]    [Pg.434]    [Pg.132]    [Pg.164]    [Pg.943]    [Pg.425]    [Pg.429]    [Pg.46]    [Pg.93]    [Pg.100]    [Pg.558]    [Pg.204]    [Pg.288]    [Pg.439]    [Pg.185]    [Pg.276]    [Pg.48]    [Pg.254]    [Pg.26]    [Pg.181]    [Pg.96]    [Pg.100]    [Pg.107]    [Pg.246]    [Pg.259]    [Pg.64]    [Pg.68]    [Pg.87]    [Pg.89]    [Pg.104]    [Pg.116]    [Pg.127]    [Pg.397]    [Pg.1159]    [Pg.826]    [Pg.37]    [Pg.315]    [Pg.99]    [Pg.182]    [Pg.47]    [Pg.141]    [Pg.274]    [Pg.125]    [Pg.126]    [Pg.47]    [Pg.974]    [Pg.90]    [Pg.32]    [Pg.1169]   


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Binding metallic

Guanin

Guanine

Guanine metal binding

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