Guanidinium derivatives

Bicyclic guanidinium derivatives have also been incorporated into bis(guanidinium) receptors capable of recognising tetrahedral oxoanions, particularly polyphosphate residues of important biological molecules. The flexibility of receptor 4.31 allows the two guanidinium arms to swing into a mutually perpendicular arrangement in order to effectively complex polyphosphates even in water. 

Buschmann, H. J., Dong, H., Mutihac, L., and Schollmeyer, E. (1999) Complex formation between crown ethers and urea and some guanidinium derivatives in methanol, J. Thermal Anal. Color. 57, 487-491. 

Frelin, C., Vigne, P Barbry, P Lazdunski, M. (1986). Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. Eur. J. Biochem. 154,241-245. 

The Anslyn group has pioneered supramolecular displacement assays as a distinctive method of analysis. A typical example used a tripodal molecule, or podand, to determine the amount of citrate in drinks and the quality of wine made from Pinot Noir grapes [7], The initial work on citrate utilized a complex between a tris(guanidinium) derivative of 1,3,5-triethylbenzene with a fluorescent dye, car-boxyfluorescein. In the presence of citrate the dye is ejected and replaced with the... 

Ohara, K., Smietana, M., and Vasseur,. -J. (2006) Characterization of specific noncovalent complexes between guanidinium derivatives and single-stranded DNA by MALDI. /. Am. Soc. Mass Spectrom., 17 (3), 283-291. 

HSO3- Polymer Guanidinium derivative ionophore, PVC, ortho-nitrophenyloctylether CI04- -2.2, cr <-3.0, Sar -2.3... 

The new fluorescent pyrrolopyrimidinium compound 124 has been formed by Maillard reaction of 3-deoxyglucosone with n-butylamine, and likewise the novel imidazolone 125 from its reaction with lV-benzoyl-arginine. ° The synthesis of cyclic guanidinium derivatives incorporating 1,3-diamino-1,3-dideoxy-tetritol moieties as glycosidase inhibitors is detailed in Chapter 9, section 3.7. 

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