GTP Binding Proteins in Platelets

Bruce R. Lester Knowledge Frontiers, LLC and Biomedical Engineering Center University of Minnesota Minneapolis, MN 55455, USA 

Brace Lester, Ph. D., has more than 20 years of research experience in biological and biomedical research working in both industry and academic environments. In conjunction with several other faculty members at the University of Minnesota, he founded Knowledge Frontiers, which specializes in technology assessment and scientific due diligence. Over the years. Dr. Lester has been involved in studying the role of G-proteins in the adhesion, motility and invasion of metastatic cancer cells. 

There are four primary signaling mechanisms, each employing a unique strategy to breach the barrio posed by the lipid bilayer of die cell plasma membrane. These four established signaling mechanisms do not account for all the signals crmvqred across cell membranes, however, they do transduce many of the most important signals used in nature. 

Intracellular Receptors that Regulate Gene Expression 

Members of this mily are tiansmembrane receptors which are gated (opened or closed) by extracellular hormones, neurotransmitter, etc. and include channels for Na and Ca. These receptors transmit their signal across the plasma membrane by changing the transmembrane conductance of the relevant ion and thereby alter the electrical potential across the membrane. 

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