Group VILA Derivatives

Heats of formation for a complete set of Group VILA fluorides are unavailable, but a set of xenon fluoride cations, isoelectronic with iodine fluorides, exhibits the alternating pattern expected for odd- and even-electron molecules. The original energy-level diagram for stepwise fluorine dissociation is shown in Fig. 5. The tabulated values were derived from the ionization energies of XeF and the threshold values for XeFJ — XeF, - + F, where n is even (27), together with heats of formation obtained by reaction calorimetry (137). 

Compound 165 and its derivatives inhibit serine protease enzymes such as TF/factor Vila and Xa (tissue factor) <2004USP0235852>. Benzofurans 166 and 167, which have transposed functional groups, are both TF/factor X inhibitors. Tissue factors are involved in the release of thrombin, so these compounds are applied to the treatment of clotting disorders <2003W003082847, 2005JPP2005120080>. Diarylbenzofuran 168 is used to inhibit bone loss <1996USP5489587>. 

It is well known from extensive electron-spin resonance (ESR) studies [4-6] that organic halides in conjunction with an organometallic derivative of a transition element of groups VIA, VILA, and VIII, with the metal in a low... 

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