Group 12 binding modes

To study the binding mode of the yS-D-galactopyranosyl residue of the Lewis b human blood-group determinant to its monoclonal antibody or to a lectin, methyl 2-acetamido-2-deoxy-3-0-(6-deoxy-6-fluoro-2-0-a-L-fuco-pyranosyl-y -D-galactopyranosyl)-4-0-a-L-fucopyranosyl-/ -D-glucopyrano-side was synthesized. ... 

The lack of structural detail for interactions involving labile metals, particularly the Group I ions, is problematic and here model compounds are proving useful. A range of binding modes for Na+ and K+ ions involving both T-02 and T-04 have been realized with Nl-alkylated thymi-... 

Figure 16 The predicted binding mode of compound 23 in the pY+3 pocket of the Src SH2 model. The branch point in the pY+3 bisallyl group allows favorable binding interactions to occur. (From Ref. 30.)...

Another study of a synthetic siderophore analog of mixed cathechol and hydroxamate donor groups exhibited similar spectral shifts with pH as observed for tris-catecholate side-rophores, consistent with a salicylate-binding mode shift (102). While this synthetic siderophore mimic supports the growth of many species of bacteria, it also exhibits a low iron-binding affinity relative to other hexadentate siderophores, with a pFe value of 18.3 (see L(cat2hydroxamate) Table HE). 

Fig. 11. Catecholate-to-salicylate-binding mode shift in catechola-mide donor group siderophores, such as enterobactin (1) and enter-obactin analogs.

Clare, R. A. Mueller, and K. Houseman, Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition Evidence for multiple binding modes, J. Med. Chem. 34 1222 (1991). 

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