Groove binding/intercalation

There are several modes of interactions related to compound-DNA binding such as covalent binding, noncovalent groove binding, intercalation, non-specific external association, cross-linking, etc. However, some of the well-known examples are presented in this chapter. [Pg.388]

Araki K, Yoshikawa I (2005) Nucleobase-Containing Gelators. 256 133-165 Armitage BA (2005) Cyanine Dye-DNA Interactions Intercalation, Groove Binding and Aggregation. 253 55-76... [Pg.256]

The dynamics of intercalation of small molecules with DNA, groove binding and binding to specific sites, such as base pair mismatches have been studied by stopped-flow,23,80 108 temperature jump experiments,26,27,94 109 120 surface plasmon resonance,121 129 NMR,86,130 135 flash photolysis,136 138 and fluorescence correlation spectroscopy.64 The application of the various techniques to study the binding dynamics of small molecules will be analyzed for specific examples of each type of binding. [Pg.186]

There are two principal modes by which drugs can bind non-covalently to DNA intercalation and external groove binding. [Pg.150]

EPR complex. More surface binding into minor groove than intercalation - With complex derivatized by stable nitroxide detection of 3 different + 64... [Pg.39]

Armitage BA (2005) Cyanine Dye-DNA Interactions Intercalation, Groove Binding and... [Pg.279]

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