Griseofulvin Ethanol

Examples of solvent-mediated transformation monitoring include the conversion of anhydrous citric acid to the monohydrate form in water [235,236], CBZ with water [237] and ethanol-water mixtures [238,239], and cocrystallization studies of CBZ, caffeine, and theophylline with water [240]. Raman spectroscopy was used to monitor the crystallization rate and solute and solvent concentrations as griseofulvin was removed from an acetone solution using supercritical CO2 as an antisolvent [241]. Progesterone s crystallization profile was monitored as antisolvent was added [242]. 

Some populations, most notably East Asians, exhibit an unusual response after drinking ethanol. The symptoms include facial flushing, vasodilation, and tachycardia. These individuals apparently have a genetic deficiency of the enzyme aldehyde dehydrogenase, which leads to an accumulation of acetaldehyde even after they drink relatively small amounts of ethanol. If drugs such as metronidazole, griseofulvin, quinacrine, the hypoglycemic sulfonylureas, phenothiazines, and phenylbutazone are coadministered with ethanol, a similar accumulation of acetaldehyde may occur. 

MA-MVE, MA-MVE ethyl ester, MA-MVE nonylphenoxy-poly-(ethylenoxy) ethanol griseofulvin (antifungal, antibiotic) 146... 

X Griseofulvin—determination in blood by the spectrofluorimetric method of Bedford, Child and Tomich. The only known metabolite, 6-desmethyl-griseofulvin, does not fluoresce and the extraction procedure recommended does not remove fluorescent substances from the blood. More recently, however, it has been shown by the same workers that certain drugs, such as acetylsalicylic acid and quinine, may cause high results. The method is based on extraction of the antibiotic into ether, evaporation of the extract to dryness and solution of the residue in 1 per cent aqueous ethanol. The fluorescence of this solution is compared with that of a standard griseofulvin solution, both solutions being activated at 295 mfi and analysed at 450 m. ... 

Griseofulvin is a white to creamy or yellowish white, odourless crystalline powder. It is practically insoluble in water, slightly soluble in methanol and ethanol, soluble in acetone and chloroform, and freely soluble in dimethylfotmamide and tetrachloroethane. Griseofulvin is stable at room temperature and to light exposure. Typical preparations include ... 

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