Grignard regents

A great many alcohols can be obtained from Grignard reactions, depending on the reactants- For example, Grignard regents react with formaldehyde,... 

Among Michael acceptors, direct addition is most likely with unsaturated aldehydes and acid chlorides, Michael addition most likely with ketones or esters. Hence Grignard regents add directly " to aldehyde (10) and Michael fashion to ester (11). 

Alkyl- or aryl-cycloheptatrienes are formed readily by the reaction of tropylium salts with Grignard regents or with organo-lithium derivatives [3,16,19,83]. For example by using vinyl magnesium chloride, vinylcycloheptatriene and hence vinyltropylium salts have been prepared [32]. With lithium cyclopentadienide cyclopenta-dienylcycloheptatriene is formed and not an ionic tropylium cyclopentadienide [19,35] ... 

By carbonation of Grignard regents. Grignard reagents react with carbon dioxide to yield magnesium carboxylates. Acidification produces carboxylic acids ... 

Chlorination followed by reaction of Grignard regents or organo-lithlum compounds... 

Draw the structure of the Grignard regent that is abbreviated BuMgBr in the reaction. 

A variation used the amine moiety of an amino-alkyne such as 1.167 rather than a Grignard regent. Condensation of the corresponding alkyne anion with carbon dioxide gave 4-(N,N-dimethylamino)but-2-ynoic acid, 1.168. Catalytic hydrogenation of the triple bond gave 4-(N,N-dimethylamino)but-2-enoic acid,... 

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