Grignard reagents computational studies

Recently, semiempirical PM3 computational analysis (568) and first ab initio study (569) of the nucleophilic addition to chiral nitrones of Grignard reagents have been carried out. The data revealed that all reactions are exothermic and proceed through /w-complexation of nitrones with the organometalic reagent. 

For reviews of the addition of organometallic compounds to carbonyl groups, see Eicher, T., in Patai, S. The Chemistry of the Carbonyl Group, pt. 1, Wiley, NY, 1966, pp. 621-693 Kharasch, M.S. Reinmuth, O. Grignard Reactions of Nonmetallic Substances, Prentice-Hall Englewood Cliffs, NJ, 1954, pp. 138-528. For a review of reagents that extend carbon chains by three carbons, with some functionality at the new terminus, see Stowell, J.C. Chem. Rev. 1984, 84, 409. For a computational study of this reaction, see Yamazaki, S. Yamabe, S. J. Org. Chem. 2002, 67, 9346. 

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