Grignard reagents action

Diethyl ether is a mobile, colourless liquid having b.p. 35° and dy 0720. It has a characteristic odour, and a burning taste. It is used chiefly as a solvent, and was formerly widely used as an anaesthetic owing to its chemical non-reactivity, it is very seldom used actually as a reagent, except in the preparation of Grignard reagents (p. 280) where probably its chemical properties reinforce its solvent action. 

Nitriles also react w ith Grignard reagents to give ketones, which arise from the hydrolysing action of the dilute sulphuric acid on the intermediate addition product. Acid amides beha e similarly. 

A general method for the synthesis of l -alkenes is provided by the action of a Grignard reagent upon allyl bromide, for example ... 

Action of the Grignard reagent upon formaldehyde, for example ... 

Action of the Grignard reagent upon an aldehyde, for example (CH3)2CmigBr + CH3CHO —> (CH3)2CHCH(OMgBr)CH,... 

By the action of a dialkyl sulphate upon a Grignard reagent, for example CsH.CHjCl-1-Mg CeH.CHjMgCl C,H,CHjMgCl -1- (C,Hj),SO, — CeHjCH.CH.CH, MgCl(SOAH )... 

On this basis the formation of 1-alkylhydrocotarnines by the action of Grignard reagents on cotarnine, investigated by Freund and collaborators, is represented as taking place in the following way —... 

The reaction of Grignard reagents with the keto group of 5a-cholestan-3-one (7) was first described in 1937/ In a later study, Barton obtained the two epimeric tertiary alcohols (8) and (9), in a ratio of 40 60 by exposing (7) to the action of methyl Grignard reagent. 

The action of Grignard reagents on 20,20-ethylenedioxy-12-ketones and 20a-hydroxy-12-ketones also shows that the attack of methylmagnesium iodide on 12-ketones proceeds mainly from the i -side of the steroid mole-cule. ... 

M-C(t bonds can be formed by each of the metals. The simple alkyls and ai7ls of Ag are less stable than those of Cu while those of Au have not been isolated. Copper alkyls and ai7ls are prepared by the action of LiR or a Grignard reagent on a Cu halide ... 

In 1934, French chemist Hoch reported that the action of phenylmagnesium bromide on the oxime of propiophenone (3) at elevated temperature gave two products. One was aziridine 4 and the other was erroneously assigned as hydroxylamine 5. In the subsequent years (1939 onward), Campbell at the University of Notre Dame determined that the purported hydroxylamine 5 was actually P-hydroxylamine 6. The scope of the Grignard reagents was extended to both aryl and aliphatic Grignard reagents. 

Hoshino and his co-workers reported that treatment of the Grignard reagent obtained from tryptamine (23), by the action of a suitable alkyl magnesium halide, with methyl iodide in benzene did not give the expected indolonino derivative 24 instead dinordeoxyeseroline (25) was obtained. 

Aeetyl-2-methylindole (116) can readily be obtained by the action of acetjd chloride on the 2-methylindole Grignard reagent in ether. ... 

Mingoia reported that 2-chloroacetyl-3-methylindole (139) was obtained by the action of chloroacetyl chloride on the skatole Grignard reagent. ... 

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