Grignard reagents acetyl chloride

The Grignard reagent from 2-thenyl chloride can be obtained by the use of the "cyclic reactor.However, rearrangement occurs in its reaction with carbon dioxide, ethyl chlorocarbonate, acetyl chloride, formaldehyde, and ethylene oxide to 3-substituted 2-methylthio-phenes, Only in the case of carbon dioxide has the normal product also been isolated. 

Acetyl-3-methyIindoIe (117) was obtained when the. skatole Grignard reagent was treated with acetyl chloride at 100° in the absence of Solvent, but l-acetyl-3-methylindole (118) was obtained when the... 

By the consecutive action of sulfur and acetyl chloride on the 2-methyliiidole Grignard reagent Oddo obtained a violet solid (m.p 311°-312°), described as 3- -acetylthio-2-methylindole (398), together R. V. Jardine and R. K. Brown, Can. J. Chem. 42, 2626 (1964). 

Acetic formic anhydride has been prepared by the reaction of formic acid with acetic anhydride2 3 and ketene,4,5 and of acetyl chloride with sodium formate.6 The present procedure is essentially that of Muramatsu.6 It is simpler than others previously described and gives better yields. It is easily adapted to the preparation of large quantities, usually with an increase in yield. Acetic formic anhydride is a useful intermediate for the formyl-ation of amines,3,7 amino acids,8,9 and alcohols,2,10 for the synthesis of aldehydes from Grignard reagents,11 and for the preparation of formyl fluoride.12... 

They utilized the reaction between indole Grignard reagents and either 3-acetyl-pyridine or nicotinoyl chloride to give the target structures 54 and 365, after the appropriate reduction. None of these compounds displayed antitumor activity anywhere comparable to that of ellipticine. 

C-sodium acetate is produced by the reaction of the Grignard reagent, methylmagnesium bromide in diethyl ether, with cyclotron-produced nC-carbon dioxide at -15°C (Oberdorfer et al, 1996). After reaction, the product is allowed to react with O-phthaloyl dichloride to produce nC-acetyl chloride, which is then hydrolyzed to 11C-acetate with saline. The solution is filtered through a 0.22-pm membrane filter. 11C-acetate has been found to be stable at pH between 4.5 and 8.5 for up to 2 h at room temperature. The overall yield is about 10-50%. It is used for the measurement of oxygen consumption (oxidative metabolism) in the heart, since acetyl CoA synthetase converts 11C-acetate to acetyl coenzyme A after myocardial uptake, which is metabolized to 11C-C02 in the tricarboxylic acid cycle. 

Bis(phenyl acetyl)benzene was obtained from the reaction of 1,4-dicyanobenzene with Grignard reagent of benzyl chloride, mp. 175-177 C ( 54.4% yield ), and recrystallized from ethylQ acetate to yield white or light yellow crystals, mp. 178-180 C. 

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