Grignard cleavage with

Methods of synthesis for carboxylic acids include (1) oxidation of alkyl-benzenes, (2) oxidative cleavage of alkenes, (3) oxidation of primary alcohols or aldehydes, (4) hydrolysis of nitriles, and (5) reaction of Grignard reagents with CO2 (carboxylation). General reactions of carboxylic acids include (1) loss of the acidic proton, (2) nucleophilic acyl substitution at the carbonyl group, (3) substitution on the a carbon, and (4) reduction. 

Esters cleavage with methoxide Alcohols cleavage by Grignard reagents [70, 71]... 

Substituted dibenzothiophenes 156 react with Grignard reagents to give products of the thiophene ring cleavage. With a chiral Ni catalyst, axially chiral biaryl compounds 157 can be obtained in high enantioselectivities (equation 93) . ... 

The formation of 183 by reaction of 182 with HC=CMgBr can be readily achieved. As in the formation of the Grignard reagent in THF, a small amount of BrMgC CMgBr is formed and a disubstituted ethyne is found as a by-product which remains in the residue after distillation. The formation of 184 from 183 by cleavage with HBr at -38 °C occurs easily. Under the conditions used, no addition of HBr to the C C bond is observed. Finally, reduction to 185 is carried out (54). 

The silicon linker 1.17 (74), prepared by Grignard reaction of a 4-bromoarylsilane with commercial formyl PS resin, was used to support acids, alcohols, and amines either as such via its acyl imidazole derivative cleavage with TBAF (tert-butylam-monium fluoride) in DMF for 3 h at 60 °C, or with CsF in DMF for 18-24 h at 90 °C validated the release of the three different functionalities. 

Dioxolanes, heterolytic ring cleavage with Grignard reagents 90UK401. 

The silanorbomenes 1, 2, and 3 can be synthesized according to the literature [1, 2]. Hydrogen chloride cleavage of 3 leads to the silicon chlorinated precursor of 13, which is obtained by a Grignard reaction with naphthyl magnesium bromide in high yield (86 %). Similarly, 15 is available from HCl cleavage of 1 and reaction of the latter with fluorenyl lithium. The silicon-chlorinated silacyclobutanes 7, 8, and 11 are synthesized by [2+2]-cycloaddition of dichloroneopentylsilene with isoprene and dimethylbutadiene, respectively [3],... 

Other cleavage procedures listed in Section 5.3 include use of a Grignard reagent to generate alcohols, the synthesis of amines by cleavage with hydrazine (ADCC linker), and the generation of tertiary amines by Hoffmann-elimination (acrylic acid linker). 

Substituted 1-isoindolinones are synthesized from MN-dimethylaminophthalimide via reaction with organolithiums (or Grignard reagents), deoxygenation with EtiSiH-CF3COOH, and N—bond cleavage with Zn in HOAc. 

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