Greening organic chemistry laboratories

Goodwin, T.E. 2004. An asymptotic approach to the development of a green organic chemistry laboratory. Journal of Chemical Education, 81 1187-90. 

Leung SH, Angel S A. Solvent-free Wittig reaction a green organic chemistry laboratory experiment. J Chem Ed 2004 81 1492-3. 

Figure 5.1 The green organic chemistry laboratory at the University of Oregon, with students working on open laboratory benches rather than in fume hoods.

Doxsee, K., and J. Hutchinson. 2004. Green Organic Chemistry Strategies, Tools, and Laboratory Experiments. 1st ed. Florence, KY Brooks/Cole. 

Sophomore Level Eall Winter Term Green Laboratory Experiments Organic Chemistry Laboratory University of Oregon James Hutchison... 

Palladium-catalyzed cross-couplings are among the most important reactions in modem organic chemistry for carbon-carbon bond formation 26), Yet, these reactions are rarely mentioned in introductory organic chemistry texts or in laboratory manuals (27). Below we present microscale, green variations of two such reactions that we have developed for the introductory organic chemistry laboratory. 

We are indebted to Shelly Bradley and Linda Desrochers for their dedicated assistance and advice, to our colleagues for their support and wise counsel, and to our many excellent organic chemistry students who helped troubleshoot the experiments discussed herein. We also are grateful for an early donation from an anonymous Hendrix alumnus to help us initiate our green organic chemistry and general chemistry laboratory programs. 

For notable exceptions, see (a) Clayden, J. Greeves, N. Warren, S. Wothers, P. Organic Chemistry, Oxford University Press Oxford, 2001 (b) Doxsee, K. M. Hutchison, J. E. Green Organic Chemistry, Strategies, Tools, and Laboratory Experiments, Thomson Brooks/Cole Belmont, CA, 2004. 

Synthesis and Photochromism of 6-Nitrospiropyran A Green Chemistry Preparation for Organic Chemistry Laboratory. Abstr. Pap.—Am. Chem. Soc. 2006, 231, CHED-283. (e) Wetter, E. Levy, I. J. Multicomponent Zeolite-Catalyzed Synthesis of p-Acetamido Ketones A Green Chemistry Laboratory Experience. Abstr. Pap.—Am. Chem. Soc. 2006, 231, CHED-272. (f) Hamel, L. J. Levy, I. J. Analyzing Green Chemistry A... 

Doxsee K M, Hutchison J E (2006) Green organic chemistry Strategies, tools, and laboratory experiments. Brooks/Cole. 

The book examines the scale-up of microwave-promoted chemistry and describes the various approaches and the current commercially available microwave reactors available for scale-up. It also discusses microwave heating as a tool for teaching in the undergraduate organic chemistry laboratory. It explores curriculum, the broad range of reactions that can be performed, and the incorporation of green chemistry principles. 

Lang PT, Harned AM, Wissinger JE. Oxidation of bomeol to camphor using Oxone and catalytic sodium chloride a green experiment for the undergraduate organic chemistry laboratory. J Chem Educ 2011 88 652-6. 

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