Green chemistry derivatization

Pollution Prevention via Molecular Recognition and Self Assembly Non-Covalent Derivatization. Warner, J. C., in Green Chemistry Frontiers in Benign Chemical Synthesis and Processes Anastas, P. and Williamson, T. Eds., Oxford University Press, London, pp 336 - 346. 1998. 

Cannon, A.S. Warner, J.C. Noncovalent derivatization green chemistry applications of crystal engineering. Crystal Growth and Design 2002, 2, 255. 

The concept of efficient and selective synthesis in water has been confirmed as the rates, yields, and selectivity were observed for many reactions. Some of the reactions that were only considered possible in organic solvents are now being conducted using water as solvent, and this is very much at the forefront of solvent-replacement research following green chemistry principles. The low solubility of substrates in pure water at room temperature can often be overcome by use of organic cosolvents, ionic derivatization, surfactants, or hydrophilic auxiliaries. 

Since there are several chapters in this book that are devoted to the medical applications of polyesters, which the readership is encouraged to read, the emphasis of this chapter therefore is on reviewing the strategies and chemistries that have been employed to derivatize polyester backbones. In order to ensure the relevance of these backbone modification approaches to current topics in medicine and the green technologies, the chapter focuses on paradigms that have generality to either a polymer family or a routine synthesis route. 

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