Grb2 inhibitor

Gay B, Suarez S, Caravatti G et al (1999) Selective Grb2 inhibitors as anti-Ras therapy. Cell 83 235-241... 

Fig. 10. Experimentally determined complexes of the Grb2 SH2 domain with a pTyr-con-taining oligopeptide (left, lBMB.pdb [71]) and inhibitor 52 (right, lCJl.pdb [147]). Even though 52 lacks the pTyr+3 residue for forming the pi turn conformation, the residues pTyr, Ac6c and Achec bind in the proposed mode to Grb2...

Figure 1.14 NMR-structure of the Grb2-SH2 domain in complex with inhibitor 39. A central antiparallel P-sheet in the protein is flanked by two a-helices, with peptide binding mediated by the sheet, intervening loops, and one of the helices. The specific recognition of phospho-tyrosine involves cation-tr interactions between...

Schoepfer J, Fretz H, Gay B et al (1999) Highly potent inhibitors of the Grb2-SH2 domain. Bioorg Med Chem Lett 9 221-226... 

Others Rah GDP dissociation inhibitor alpha SH3-domain GRB2-hke 2 XIST nuclear receptor 1, 3... 

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