Grapes chemopreventive properties

In addition to their possible prooxidant activity (see above) polyphenols and flavonoids may influence cancer cells via their antioxidant properties. Recently, Jang et al. [219] studied cancer chemopreventive activity of resveratrol, a natural polyphenolic compound derived from grapes (Chapter 29). These authors showed that resveratrol inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. Flavonoids silymarin and silibinin also exhibited antitumor-promoting effects at the stage I tumor promotion in mouse skin [220] and manifested antiproliferative effects in rat prostate cancer cells [221]. 

As described above, grape pomace is considered a valuable source of polyphenols. The biological and fimctional properties of these compounds are intensively studied. Over the years, researchers of different disciplines have investigated the mechanisms of chemoprevention, anticardiovascular disease and other disease prevention activities of grape... 

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