Grapefruit juice components

Tassaneeyakul W, Guo LQ, Fukuda K, Ohta T, Yamazoe Y. Inhibition selectivity of grapefruit juice components on human cytochromes P450. Arch Biochem Biophys 2000 378(2) 356-363. 

Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999 48(4) 543-552. 

Paine MF, Criss AB, Watkins PB. Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties. Drug Metab Dispos 2004 32(10) 1146-1153. 

Takanaga H, Ohnishi A, Matsuo H, Sawada Y. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells. Biol Pharm Bull 1998 21(10) 1062 1066. 

The GIT supplements the kidney in the elimination of wastes and toxins. The P-glycoprotein of enterocytes, which is implicated in multi-drug resistance, plays a critical role. This export carrier exhibits varying responses to the different polyphenols present in green tea (Wang et al, 2002), and is inhibited by one or more components of grapefruit juice (Wagner et al, 2001). It is... 

A good example is l-p-mcnthene-8-thiol the (R) enantiomer is an important flavor component of grapefruit juice, having a very low olfactory threshold of... 

Fukuda K, Guo L, Ohashi N, Yoshikawa M, Yamazoe Y. Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interactions. J Chromatogr 2000 741(B) 195-203. 

Fukuda K, Ohta T, Oshima Y, Ohashi N, Yoshikawa M, Yamazoe Y. Specific CYP3A4 inhibitors in grapefruit juice furocoumarin dimmers as components of drug interaction. Pharmacogenetics 1997 7 391-396. 

He K, Iyer KR, Hayes RN, Sinz MW, Woolf TE, Hollenberg PE. Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem Res Toxicol 1998 ll(4) 252-259. 

Le Goff-Klein N, Koffel JC, Jung L, Ubeaud G. In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice. Eur J Pharm Sci 2003 18(l) 31-35. 

Another important interaction is that of limonin with the bitter flavanone glycoside naringin. Both of these bitter substances are present in grapefruit juice and Guadagni et al. (25) found that they interact at subthreshold levels in an additive way. Less than threshold amounts of limonin or naringin contribute to the bitterness of a mixture of the two compounds. The bitterness of the mixture can be predicted by adding the taste-unit contribution of each component (taste unit = concentration/ threshold). 

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