Granule Growth and Consolidation

Breakage mechanisms will be treated in the following section. Here, we focus particularly on growth and consolidation mechanisms. 

K oc (Iwhere is the reduced elastic modulus. Granule deformation is initially dominated by inelastic behavior of contacts during collision (35). 

Low hepr mixers Ruid-beds Pans Drum  

it should be noted that the process or formulation itself cannot define whether it falls into a low- or high-agitation intensity process. As discussed more fully in the following sections, it is a function of both the level of shear as well as the formulation deformability. A very stiff formulation with low deformability may behave as a low deformability system in a high-shear mixer, or a very pliable formulation may act as a high-deformable system in a fluid-bed granulator. 

In most cases, granule deformability increases with increasing moisture, decreasing binder viscosity, decreasing surface tension, decreasing interparticle 

---

FIG. 21-108 Granule porosity and mean (pellet) size. Typical regimes of granule growth and consolidation. [After Kapur, Adv. Chem. Eng., 10, 55 (1978) Chem. Eng. Sci., 26,1093 (1971).]... 

---