Granule cells kainate receptors

Fig. 4. (A-J) Distribution of kainate receptor subunit mRNAs in the adult rat brain (X-ray film autoradiographs, coronal sections). Arrowheads in E and F mark neocortical layer III cells expressing the GluR7 gene. AV, anteroventral thalamic nucleus BST, bed nucleus stria terminalis CC, corpus callosum white matter tract Cg. cingulate cortex Cpu, caudate putamen DG, denate granule cells DM, dorsomedial hypothalamic nucleus GP, globus pallidus MPA, medial preoptic area Pir, piriform cortex Rt, reticular thalamic nucleus SCh, suprachiasmatic nucleus. Scale bar, 3.2 mm (Wisden and Seeburg, 1993a).

PHARMACOLOGICAL EEEECTS AND MECHANISMS OF ACTION Topiramate reduces voltage-gated Na+ currents in cerebellar granule cells and may act in a manner similar to phenytoin. In addition, topiramate activates a hyperpolarizing K+ current, enhances postsynaptic GABA -receptor currents, and also limits activation of the AMPA-kainate-subtype(s) of glutamate receptor. Topiramate also is a weak carbonic anhydrase inhibitor. 

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