Granule cells and parallel fibers

In early studies it was found that in staggerer , weaver and reeler mutant mice which have almost complete or partial loss of their granule cells (McBride et al., 1976a Hudson et al., 1976) and in rats or mice that lost their granule cells by a viral infection or 

Specific markers for granule cells are few. Seyfried et al. (1983), concluded from biochemical analysis in weaver mutant mice that the ganglioside GD,A was more concentrated in granule cells. Webb and Woodhams (1984) developed three monoclonal 

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Fig. 7. Granule cells and parallel fibers after an injection of biocytin in lobule X of the cerebellum of the rat. A. Biocytin labelled granule cell. B. Golgi-impregnated granule cells and parallel fibers in transverse section. Cajal (1911). C. biocytin injection site in granular layer and labelled parallel fibers in molecular layer. D. bifurcation site of labelled parallel fibers. E. labelled varicose parallel fibers. Abbreviations A molecular layer B granular layer C white matter a granule cell axon b bifurcation of granule cell axon d Purkinje cell f Purkinje cell axon g granular layer I injection site m molecular layer. Bars in A = 12 /tm, in C = 500 nva, in D and E = 50 //m. Courtesy of Dr. T.J.H. Ruigrok.

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