Gram-positive/negative bacteria imipenem

These agents have broad-spectrum activity, including gram-positive, gram-negative, and anaerobic bacteria. Imipenem and meropenem are active against P. aeruginosa and enterococci, but ertapenem is not. All may be associated with Candida superinfections. Rarely used for UTIs. 

Microbiology Imipenem-cilastatin has a high degree of stability in the presence of -lactamases, including penicillinases and cephalosporinases produced by gram-negative and gram-positive bacteria. 

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