Gram-negative bacteria region

Practically all anaerobic Gram-negative bacteria are resistant to lincosamides. Resistance to lincosamides can occur because of the inability of drugs to permeate through the cellular membrane of bacteria, or because of changes in the ribosomal-binding regions. 

Y. A. Knirel and N. K. Kochetkov, The structure of the lipopolysaccharides of Gram-negative bacteria. II. The structure of the core region, Biochemistry (Moscow), 58 (1993) 84-99. 

Figure 2 Siderophore-mediated iron-uptake systems in E. coli. Siderophore-iron complexes bind to transporter proteins located in the outer membrane (also known as OM), a barrier that is characteristic of Gram-negative bacteria. The region between the outer and inner is known as the periplasmic space. Specific carrier proteins such as FhuD transport iron fi om the outer membrane to the inner or cytosolic membrane (also known as CM). The TonB/ExbB/ExbD complex spans the inner and outer membranes and interacts with FepA, as shown, as well as all of the outer membrane receptors. The linkage that the TonB/ExbB/ExbD complex provides between the inner or cytosolic membrane to the outer membrane is thought to allow transmission of sufficient energy from the cytosol to drive siderophore-iron uptake across the outer membrane...

Glycero-u-manno-heplose is a monosaccharide residue found in bacterial polysaccharides, predominantly in the inner core region of lipopolysaccharides of Gram-negative bacteria. The h-glycero form is the most abundant, but the D-glycero isomer has also been found [1,2]. 

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