Gradient elution liquid chromatography, electrochemical

Typically, in gradient elution liquid chromatography, electrochemical detection has been difficult due to base-line shifts that result as a consequence of the altered mobile phase composition. However, a unique property of micelles allows for much improved compatibility of gradients (i.e. gradient in terms of micellar concentration or variation of small amount of additive such as pentanol) with electrochemical detectors. This has been demonstrated by the separation and electrochemical detection of phenols using micellar gradient LC (488). A surfactant (apparently non-micellar) gradient elution with electrochemical detection has also been successfully applied for the assay of some thyroid hormones by LC (491). [Pg.60]

Micellar gradient elution liquid chromatography with electrochemical detection with sodium dodecyl sulfate has been used to separate phenols [186]. [Pg.274]

Khaledi MG, Dorsey JG (1985) Hydro-organic and micellar gradient elution liquid chromatography with electrochemical detection. Anal Chem 57 2190-2196 Kissinger PT (1989) Biomedical applications of liquid chromatography-electrochemistry. J Chromatogr 488 31-52... [Pg.113]

To many analysts the major limitation of electrochemical detection for liquid chromatography (LCEC) is its limited applicability to gradient elution techniques. Amperometric electrochemical detectors exhibit both the best and the worst characteristics of solute property and bulk property detectors. While the Faradaic current arises only from the solute, the non-Faradaic current arises from... [Pg.108]