GPCRs prostanoid receptors

TP receptors are members of the broader class of prostanoid receptors that appear to constitute a sub mily within the ihodopsin-like, G protein-coupled receptor super mily (3). These G protein-coupled receptors (GPCR) have as a common stmctuial characteristic seven transmembrane alphajielices coimected by alternating extracellular and intracellular loops (44,45). Figure 1 illustrates the deduced amino acid sequence and the trans-membrane topology of the human TP receptor. 

The prostanoids produce effects via five main subclasses of GPCR DP, EP, FP, IP, and TP (63). The EP receptor exists ia four subtypes,... 

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