GPCRs focused screening libraries

Jimonet, P. and Jager, R. (2004) Strategies for designing GPCR-focused libraries and screening sets. Current Opinion in Drug Discovery el Development, 7, 325-333. 

Using such a table, it is then possible to sort a whole family of GPCRs according to the type of SAR that the receptor displays. This can, in turn, be used to design focused libraries with which to screen particular subsets of receptors (see below), or to define search criteria with which to trawl... 

Bissantz, C., Schalon, C., Cuba, W., and Stahl. M. (2005) Focused library design in GPCR projects on the example of 5-HT (2c) agonists comparison of structure-based virtual screening with ligand-based search methods. Proteins, 61, 938—952. 

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