Goldfish chlorophenol accumulation

Figure 8. The bioconcentration ratios of chlorophenols in goldfish at 1 h exposure to their media as a function of the difference between pH and pKa. 4-CP 4-chlorophenol, 2,5-DCP 2,5-dichlorophenol, 3,5-DCP 3,5-dichlorophenol, 2,4,6-TCP 2,4,6-trichlorophenol, PCP pentachlorophenol, 2-CP 2-chlorophenol, 3-CP 3-chlorophenol, 2,4-DCP 2,4-dichlorophenol, 2,3-DCP 2,3-dichlorophenol, 2,4,5-TCP 2,4,5-trichlorophenol, 2,3,4,6-TCP 2,3,4,6-tetrachlorophenol, 2,6-DCP 2,6-dichlorophenol. Reprinted from [185] Water Res., 29, Kishino, T. and Kobayashi, K. Relation between toxicity and accumulation of chlorophenols at various pH, and their absorption mechanism in fish , pp. 431-442. Copyright (1995), with permission from Elsevier...

The present paper deals with a relation between toxicity and accumulation of chlorophenols in goldfish, Carassius auratus, PCP metabolites and their amounts excreted by the three major routes (branchial, renal and biliary) in the fish, and also with effects of pre-exposure to PCP on PCP-tolerance and on sulfate conjugation with phenol by the liver soluble fraction of the fish. 

A study has been done regarding the acute toxicity of various chlorophenols to goldfish(av. 2 g), and their accumulation by the fish. Table I (3) shows the 24-h LC50 values of tested chlorophenols and the amounts of chlorophenols found in the dead fish in the media containing the chlorophenols at the concentration most close to each 24-h LC50 value, among the test... 

Kobayashi K, Akitake H, Manadge K. 1979. Relation between toxicity and accumulation of various chlorophenols in goldfish. Bull Jap Soc Scien Fish 45 173-175. 

Stehly, G.R., Hayton, W.L. (1990) Effect of pH on the accumulation kinetics of penta-chlorophenol in goldfish. Arch. Environ. Contain. Toxicol. 19, 464—470. 

Kobayashi, K., S. Kimura, and E. Shimizu. 1977. Studies on the Metabolism of Chlorophenols in Fish—IX. Isolation and Identification of Pentachlorophenols- -glucuronide Accumulated in Bile of Goldfish, Bulletin of Japanese Society of Scientific Fisheries, vol. 43, pp. 601-607. 

Kobayashi, K., Kimura, S. and Shimizu, E. 1977. Studies on the metabolism of chlorophenols in fish - IX. Isolation and identification of pentachlorophenol-/3-glucuronide accumulated in bile of goldfish. Bull. Jap. Soc. Sci. Fish. 43 601-607. 

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