Gold toxicity

Witkiewicz, P.L. and Shaw, C.F. Ill (1981) Oxidative cleavage of peptide and protein disulfide bonds by gold(III) amechanism for gold toxicity. Journal of the Chemical Society, Chemical Communications, (21), 1111-1114. [Pg.317]

Combination with penicillamine is contraindicated as penicillamine is a metal chelator. However penicillamine can be used to treat gold toxicity. N-acetylcysteine can also increase the excretion of gold. [Pg.441]

Signs and symptoms of gold toxicity, the primary serious reaction, include decreased Hgb level, decreased granulocyte count (less than 150,000/mm ), proteinuria, hematuria, stomatitis, blood dyscrasias (anemia, leukopenia WBC count less than 4000/mm, thrombocytopenia, and eosinophilia), glomerulonephritis, nephrotic syndrome, and cholestatic jaundice. [Pg.105]

These thiolate exchange reactions are thought to lead to incorporation of gold(I) to thiolate functions in proteins and enzymes, and thence to interfere with the inflammatory process. Thiols such as 2,3-dimercaptopropanol (BAL), iV-acetylcysteine and penicillamine have also been used in the treatment of gold toxicity. Protein-bound gold is mobilized by complexation to the added thiol and can then be excreted.250,273... [Pg.877]

Gold toxicity Arsenic toxicity Contact lens related... [Pg.516]

Madhok R, Capell HA, Waring R. Does sulphoxidation state predict gold toxicity in rheumatoid arthritis BMJ (Chn Res Ed) 1987 294(6570) 483. [Pg.1529]

To predict D-penicillamine side effects, the association between side effects and various factors, such as HLA antigens [68,70,128,130,163,164], autoantibodies [165, 166], and previous gold toxicity [101, 138, 167, 168] has been studied. Wooley et al. [68] investigated... [Pg.468]

Barger BO, Acton RT, Koopman WJ, Alarcon GS. DR antigens and gold toxicity in white rheumatoid patients. Arthritis Rheum... [Pg.473]

Ostuni PA, Simioni M, Marson P,Travaglia P, Volante D, Gambari PF. Serum IgA and gold toxicity in rheumatoid arthritis lack of predicting value. Clin Exp Rheumatol 1986 4 359-362. [Pg.474]

Dodd MJ, Griffiths ID, Thomson M. Adverse reaction to D-penicillamine after gold toxicity. Br Med J 1980 26 1498-1500. Webley M, Coomes EN. Is penicillamine therapy in RA. influenced by previous gold Br Med J 1978 2 91. [Pg.478]

Report immediately early symptoms of gold toxicity such as a metallic taste or pruritus (itching). How to identify side effects ... [Pg.136]

Gran JT, Husby G, Thorsby E (1983) HLA-DR antigens and gold toxicity. Ann Rheum... [Pg.278]

Dodd MJ, Griffiths ID, Thomson M. Adverse reaction to D-penicillamine after gold toxicity. Br Med J 1980 26 1498-1500. [Pg.323]

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