Gold metal complexes

A unique method to generate the pyridine ring employed a transition metal-mediated 6-endo-dig cyclization of A-propargylamine derivative 120. The reaction proceeds in 5-12 h with yields of 22-74%. Gold (HI) salts are required to catalyze the reaction, but copper salts are sufficient with reactive ketones. A proposed reaction mechanism involves activation of the alkyne by transition metal complexation. This lowers the activation energy for the enamine addition to the alkyne that generates 121. The transition metal also behaves as a Lewis acid and facilitates formation of 120 from 118 and 119. Subsequent aromatization of 121 affords pyridine 122. 

Figure 4.19 Synthesis of gold ylid complexes, including gold(II) compounds with metal-metal...

Anthraquinone, 1-hydroxy-calcium aluminum chelate compound, 1,2 metal complexes dyes, 6,86 Antiarthritis drugs labelled gold compounds, 6, 969 metal complexes, 6,758 Antibiotic M139163,2, 974 Antibiotics ionophoric, 6, 553 metal complexes selective binding, 6, 552... 

Navarro, M., Vasquez, F., Sanchez-Delgado, R.A., Perez, H., Sinou, V. and Schrevel, J. (2004) Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 7. Synthesis and in Vitro Antimalarial Activity of New Gold-Chloroquine Complexes. Journal of Medicinal Chemistry, 47, 5204. 

Since the most abundant gold(II) complexes belonging to the Au2 formulation have been discussed above, now we will refer to nudearity higher than two. This includes complexes with more than two gold atoms in the molecule or with other metals in their composition in addition to the gold centers (see Table 3.15). 

Fernandez, E.J., Laguna, A., Lopez-de-Luzuriaga, J.M., Montiel, M Olmos, M.E. and Perez, J. (2005) Dimethylsulfoxide gold-thaDium complexes. Effects of the metal-metal interactions on the luminescence. Inorganica Chimica Acta, 358(14), 4293 300. 

Uson, R., Laguna, A. and Vicente, J. (1976) Dihaloperhalophenyl(triethylphosphine) gold(III) complexes. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 6(4), 293—305. 

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