Gold control gene expression

Very little information is available on the mechanisms that control the production of PE via the CDP-ethanolamine pathway. Factors that regulate this pathway for PE production at the level of gene expression have not yet been elucidated. In the 1970s Akesson and Sundler reported that ET catalyzes the rate-limiting step of this pathway (R. Sundler, 1975). In addition, under some metabolic conditions the supply of the substrate, DG, can limit the rate of PE biosynthesis from ethanolamine (L.M.G. van Golde, 1989). Two studies have implicated a channeling of intermediates of the pathway in the biosynthesis of PE in mammalian cells (M.W. Spence, 1989). 

Chen CC, Lin YP, Wang CW et al (2006) DNA-gold nanorod conjugates for remote control of localized gene expression by near infrared irradiation. J Am Chem Soc 128 3709-3715... 

Kawano T, Yamagata M, Takahashi H et al (2006) Stabilizing of plasmid DNA in vivo by PEG-modilied cationic gold nanoparticles and the gene expression assisted with electrical pulses. J Control Release 111 382-389... 

DNA Gold nanorod conjugates for remote control of localized gene expression by near infrared irradiation. 

---