Gold catalysis hydroamination with

In recent years, several groups have developed enantioselective tandem reactions based on the combination of gold catalysis and organocatalysis. Among them, Gong et al. reported that an achiral gold complex compatibly worked with a chiral phosphoric acid to promote a domino intramolecular hydroamination-reduction reaction, readily transforming... 

By combining an initial gold-catalyzed hydroaminative indole formation with repetitive hydroarylations, Hirano et al. [48] reported the gold-catalyzed direct construction of highly fused carbazoles by multiple cyclization. Scheme 4.28 shows one example of this chemistry, and the overall yield of this pentacyclization is excellent, highlighting the efficiency of gold catalysis. 

In 2010, Wang et al. applied the gold(I)/chiral Brpnsted acid relay catalysis to a novel three-component cascade reaction, providing direct access to structurally diverse julolidine derivatives 374 in high optical purity (Scheme 2.99). The phosphoric acid (Se)-catalyzed asymmetric Povarov reaction of 2-(2-propynyl)anihnes 365, (V-vinylcarbamate 8, and aldehydes 3 provided enantioenriched tetrahydroquinoline intermediates 372, which then underwent a hydroamination reaction under the catalysis of a gold complex to give julolidine derivatives with up to >99% ee [133]. 

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